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Experientia. 1992 Oct 15;48(10):975-80.

Mechanoelectrical transduction, ion movement and water stasis in uromodulin.

Author information

1
Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, Scotland.

Abstract

Mechanical movement of a column of the urinary glycoprotein uromodulin modulates an applied voltage. This change is a property of the glycoprotein and its interaction with the walls of the container and is related to its capacitance. The voltage modulation is not accompanied by changes in rotationally restricted water as has been reported for hyaluronic acid. Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.

PMID:
1426148
DOI:
10.1007/bf01919145
[Indexed for MEDLINE]

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