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Eur J Pharmacol. 1992 Jul 7;217(2-3):215-6.

Isoflurane anesthesia is stereoselective.

Author information

1
Laboratory of Neuroscience, NIDDK/NIH, Bethesda, MD 20892.

Abstract

The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P less than 0.005, ANOVA) difference in the potencies of these isomers ((+) greater than (-)) was observed. To our knowledge, this is the first demonstration of a stereospecific action of a volatile anesthetic in vivo.

PMID:
1425941
DOI:
10.1016/0014-2999(92)90875-5
[Indexed for MEDLINE]

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