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Biomaterials. 1992;13(10):664-7.

Microradiographic and histochemical evaluation of mineralization inhibition at the bone-alumina interface.

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  • 1Laboratory for Biocompatibility Research on Implant Materials, University of Bologna, Italy.


Microradiographic and histochemical tests were used to examine the behaviour of the bone tissue close to the alumina coating in cementless hip prostheses which were radiologically stable and explanted because of pain. The presence was detected of a decalcification stripe of the bone tissue with a thickness of about 300 microns, parallel to the prosthesis profile and in appearance not influenced by the roughness of the surface. This phenomenon was attributed to the presence of aluminium ions similarly to what happens in osteomalacic osteodystrophy in nephropathic dialysed patients. It was concluded that the phenomenon must be carefully considered because, in the long term, it could cause failure in the alumina coating.

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