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Curr Opin Cell Biol. 1992 Oct;4(5):850-5.

Regulation of cartilage and bone differentiation by bone morphogenetic proteins.

Author information

1
Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

PMID:
1419064
DOI:
10.1016/0955-0674(92)90110-x
[Indexed for MEDLINE]

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