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Curr Opin Cell Biol. 1992 Oct;4(5):760-5.

Structure, function and evolutionary relationship of proteins containing a disintegrin domain.

Author information

1
Department of Pharmacology, University of California, San Francisco 94143-0450.

Abstract

Disintegrins are soluble integrin ligands from snake venoms that disrupt cell-matrix interactions. Recently, the nuclear magnetic resonance structures of two disintegrins were determined, providing provocative molecular insight into how a disintegrin may engage an integrin. In addition, it has recently been realized that disintegrins are derived from larger multifunctional proteins, and that there is a family of membrane-anchored, disintegrin domain-containing proteins that may promote important cell-cell interactions.

PMID:
1419054
DOI:
10.1016/0955-0674(92)90098-w
[Indexed for MEDLINE]

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