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Neuron. 1992 Nov;9(5):929-42.

The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.

Author information

1
Division of Biology, California Institute of Technology, Pasadena 91125.

Abstract

In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.

PMID:
1419001
DOI:
10.1016/0896-6273(92)90245-9
[Indexed for MEDLINE]

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