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Arzneimittelforschung. 1992 Jul;42(7):914-7.

Bioavailability of vinpocetine and interference of the time of application with food intake.

Author information

1
Pharmacokinetics Department, Thiemann Arzneimittel GmbH, Waltrop, Fed. Rep. of Germany.

Abstract

In a pilot study based on an open cross-over design involving four phases, the relative bioavailability of the eburnamenine derivative vinpocetine (CAS 42971-09-5) was investigated in 8 healthy volunteers in relation to different times of drug administration relative to food intake. The substance was applied orally as 10 mg film tablets. The areas under the plasma concentration-time curves (AUC) amounted to 27.3 +/- 18.1 ng.h/ml (fasting) and 42.8 +/- 27.4 up to 54.3 +/- 38.4 ng.h/ml (non-fasting, intake before and after meal, resp.). The relative bioavailability under non-fasting conditions was found to be approx. 60 to 100% higher than under fasting conditions.

PMID:
1418055
[Indexed for MEDLINE]

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