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Arthritis Rheum. 1992 Oct;35(10):1197-201.

Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts.

Author information

1
Department of Biochemistry, Tokyo College of Pharmacy, Japan.

Abstract

OBJECTIVE:

High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease.

METHODS:

We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of extracellular matrix macromolecules and of matrix-degrading proteinases in rheumatoid synovial fibroblasts.

RESULTS:

In rheumatoid synovial fibroblasts, IL-6 by itself enhanced the production of plasminogen activator, its inhibitor, and tissue inhibitor of metalloproteinases, whereas it did not modulate the biosynthesis of precursor of matrix metalloproteinase 1 (proMMP-1) (tissue collagenase), proMMP-3 (stromelysin), or connective tissue components. However, IL-1-induced production of proMMP-1 and proMMP-3 was preferentially augmented by IL-6.

CONCLUSION:

These results suggest that in RA, IL-6 may participate along with IL-1 in fine tuning of the catabolism of connective tissue components, by modulating the balance between connective tissue-degrading enzymes and their inhibitors.

PMID:
1418006
DOI:
10.1002/art.1780351012
[Indexed for MEDLINE]

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