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Lipids. 1977 May;12(5):409-13.

Prevention of obesity in Avy/a mice by dehydroepiandrosterone.

Abstract

Dehydroepiandrosterone, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented Avy/a mice from becoming obese. Decreased accumulation of triacylglycerol accounted for a large portion of the weight difference between treated and control Avy/a mice. Hepatic lipogenesis as measured by 3H2O incorporation into total lipid was less in the dehydroepiandrosterone-treated mice. Dehydroepiandrosterone did not suppress appetite and had no apparent toxic effects at the doses used, and its weight controlling effects were reversible upon withdrawal of treatment.

PMID:
140989
DOI:
10.1007/bf02533624
[Indexed for MEDLINE]

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