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Postgrad Med J. 1992 Apr;68(798):272-6.

Use of the SeHCAT test in the investigation of diarrhoea.

Author information

1
Department of Medicine, Gloucestershire Royal Hospital, UK.

Abstract

The SeHCAT test was used to investigate possible bile acid malabsorption in 166 patients presenting to a district general hospital with chronic diarrhoea of uncertain cause. Eighty-four (51%) patients had impaired SeHCAT retention. These included 23 of 28 patients with a possible type I abnormality (terminal ileal resection or disease, previous pelvic radiotherapy), 20 of 74 with a possible type II abnormality (idiopathic diarrhoea), 32 of 45 with a possible type III abnormality (post-cholecystectomy, post-vagotomy), and 9 of 19 with diarrhoea associated with diabetes. Patients with severe bile acid malabsorption demonstrated a good response to cholestyramine whereas the response in patients with a mildly abnormal SeHCAT retention was variable. Bile acid malabsorption is an important cause of diarrhoea in patients presenting with unexplained chronic diarrhoea.

PMID:
1409191
PMCID:
PMC2399282
DOI:
10.1136/pgmj.68.798.272
[Indexed for MEDLINE]
Free PMC Article

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