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Neurosci Lett. 1992 May 11;139(1):77-82.

Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage.

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Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.


A role for ionotropic (NMDA, AMPA, and kainate) excitatory amino acid (EAA) receptors in seizure and seizure-related brain damage is well documented. To study the possible role of metabotropic (G-protein linked) EAA receptors in this regard, a highly selective metabotropic EAA agonist was injected into the hippocampus of halothane-anesthetized rats. This resulted in delayed-onset seizures and selective hippocampal neuronal damage that was indirectly mediated by NMDA receptors. This provides direct evidence for a novel role of metabotropic EAA receptors in the etiology of seizures and neuronal damage.

[Indexed for MEDLINE]

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