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No Shinkei Geka. 1992 Sep;20(9):1017-20.

[Malignant melanoma metastatic to the cavernous sinus and skull with an unknown primary origin: report of a case].

[Article in Japanese]

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Department of Neurosurgery, Toyama Medical and Pharmaceutical University.


A rare case of malignant melanoma metastatic to the cavernous sinus and skull, with an unknown primary origin, is reported. A 46-year-old man noticed diplopia, lt. ptosis and swelling in the parietal and maxillary regions. The parietal skull tumor and the maxillary lymph node were excised and histological examination revealed malignant melanoma. Because of its roentogenological characteristics, the lesion of the cavernous sinus was also thought to be the site of metastasis of malignant melanoma. This case is rare because the initial symptom was cavernous sinus syndrome, and no involvement of brain parenchyma was observed.

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