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Nature. 1992 Oct 8;359(6395):531-3.

Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials.

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Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.


In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome.

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