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J Med Primatol. 1992 Jul;21(5):275-8.

Identification of two subclasses of IgA in the chimpanzee (Pan troglodytes).

Author information

1
Department of Microbiology, Georgetown University, School of Medicine, Washington, DC 20007.

Abstract

Chimpanzee secretory immunoglobulin A (SIgA) was separated into two fractions by chromatography using the terminal galactose-binding lectin Jacalin. The SIgA fraction bound by Jacalin was cleaved by Haemophilus influenzae IgA1 protease, whereas the SIgA nonbinding fraction was not cleaved. It is proposed that these fractions represent IgA1 and IgA2 subclasses because the presence or absence of galactose-terminal oligosaccharides (Jacalin binding) and susceptibility or resistance to IgA1 protease are properties that define human IgA1 and IgA2 subclasses.

PMID:
1404336
[Indexed for MEDLINE]

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