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J Pediatr. 1992 Oct;121(4):581-4.

Intellectual development at age 12 years of children with congenital hypothyroidism diagnosed by neonatal screening.

Author information

1
Department of Pediatrics, Université de Montréal, Quebec, Canada.

Abstract

Twenty-seven patients with congenital hypothyroidism diagnosed by neonatal screening were examined at the age of 12 years. The 12 patients with severe hypothyroidism at diagnosis (thyroxine < 2 micrograms/dl (< 26 nmol/L), and area-of-the-knee epiphyses < 0.05 cm2 had a lower IQ than the 15 patients with less severe hypothyroidism (mean +/- SD, 89 +/- 17 vs 104 +/- 10; p < 0.007). Comparisons of patients and siblings confirm that this difference was due to the severity of hypothyroidism.

PMID:
1403394
DOI:
10.1016/s0022-3476(05)81150-3
[Indexed for MEDLINE]

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