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Gene. 1992 Oct 1;119(2):287-92.

Isolation and characterization of the mouse alpha-lactalbumin-encoding gene: interspecies comparison, tissue- and stage-specific expression.

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Laboratoire de Génétique Biochimique, INRA-CRJ, Jouy-en-Josas, France.


The murine alpha-lactalbumin-encoding gene (m alpha La) was isolated and completely sequenced. The 2.3-kb transcription unit shared a similar organization with that of its counterparts from other species. Sequence comparison for the proximal 5'-flanking region indicated the presence of a consensus motif that occurs in all milk-protein-encoding genes, except the kappa-casein-encoding gene. This may correspond to the binding site for the recently identified mammary-gland-specific factor. The m alpha La gene occurs in a single copy per haploid genome and is specifically expressed in the mammary gland where it is induced during late pregnancy.

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