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FEBS Lett. 1992 Oct 26;311(3):256-8.

The secondary structure of influenza A M2 transmembrane domain. A circular dichroism study.

Author information

1
Department of Biochemistry, University of Edinburgh Medical School, Scotland, UK.

Abstract

Using circular dichroism, this study investigated the secondary structure of the influenza A M2 transmembrane domain. When reconstituted into 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes, the M2 transmembrane domain was found to adopt a predominantly alpha-helical secondary structure which was unaffected by both temperature and the addition of 1-aminoadamantane hydrochloride. Reconstitution into 1,2-dioleoyl-sn-glycero-3-phosphoglycerol liposomes resulted in a marked decrease in helical content.

PMID:
1397324
DOI:
10.1016/0014-5793(92)81114-2
[Indexed for MEDLINE]
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