Format

Send to

Choose Destination
Eur J Immunol. 1992 Oct;22(10):2761-4.

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.

Author information

1
Department of Immunology, University Hospital Utrecht, The Netherlands.

Abstract

Nucleotide sequence analysis of cDNA encoded by the single member of the human immunoglobulin VH6 gene family show that blood B cells in adults, but not in neonates, frequently express somatically mutated IgM molecules. The number of mutations in VH6-encoded cDNA from adult blood ranged from 2 to 19 mutations/VH gene (average 10.1/VH gene). The distribution of silent and replacement mutations suggests that at least some of the VH6 genes were derived from B cells that were activated and selected by antigen. We conclude that the blood B cell repertoire in adult humans, in contrast to its much-studied murine splenic counterpart, is a rich source of highly mutated IgM molecules.

PMID:
1396981
DOI:
10.1002/eji.1830221046
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center