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Cell. 1992 Oct 2;71(1):169-80.

Molecular basis of human hypertension: role of angiotensinogen.

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Howard Hughes Medical Institute, Eccles Institute of Human Genetics University of Utah Health Sciences Center, Salt Lake City 84112.


Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans.

[Indexed for MEDLINE]

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