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Cancer Genet Cytogenet. 1992 Sep;62(2):180-5.

Analysis of prostatic tumor cultures using fluorescence in-situ hybridization (FISH).

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1
Department of Pediatrics, Eastern Virginia Medical School, Norfolk.

Abstract

Analysis of ten primary prostatic tumor cultures using fluorescence in-situ hybridization (FISH) with pericentromeric probes for chromosomes 7, 8, 10, 16, 17, and 18 revealed aneusomies in nine of these specimens. Classical cytogenetics by G-banding indicated that only four of those same ten specimens had any (but not consistent) clonal abnormalities. This preliminary study suggests that aneusomy is a common event in early-stage prostatic tumors, and also supports the notion that multiple chromosomes are involved. In combination with routine cytogenetic analysis, FISH is thus likely to be a powerful tool in the evaluation of prostatic cancer.

PMID:
1394106
[Indexed for MEDLINE]

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