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BMJ. 1992 Apr 4;304(6831):867-9.

Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy.

Author information

1
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London.

Abstract

OBJECTIVE:

To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype.

DESIGN:

Prospective screening study.

SETTING:

The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London.

SUBJECTS:

827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling.

MAIN OUTCOME MEASURE:

Incidence of chromosomal defects.

RESULTS:

The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal.

CONCLUSION:

Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.

PMID:
1392745
PMCID:
PMC1882788
DOI:
10.1136/bmj.304.6831.867
[Indexed for MEDLINE]
Free PMC Article

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