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Bone Miner. 1992 Sep;18(3):227-36.

On the rat model of human osteopenias and osteoporoses.

Author information

1
Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo.
2
U UT, Salt Lake City

Abstract

The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.

PMID:
1392696
DOI:
10.1016/0169-6009(92)90809-r
[Indexed for MEDLINE]

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