Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Toxicol Pathol. 1992 Aug;44(4):169-81.

Lipid peroxidation--a common pathogenetic mechanism?

Author information

1
Institute of Pathological Biochemistry, Friedrich Schiller University, Jena, Germany.

Abstract

Lipid peroxidation is considered at present as one of the basic mechanisms involved in reversible and irreversible cell and tissue damage. The current knowledge about the role of peroxidative breakdown of polyunsaturated fatty acids in the pathogenesis of various diseases has been reviewed. Lipid peroxidation leads to degradation of the lipid membrane, interaction of degradation products with intra- and extracellular targets and to the production of new reactive oxygen species during the course of the chain reaction thus leading to damage of cells and tissues. According to our current view lipid peroxidation is implicated in the pathogenesis of cancer, inflammatory processes, atherosclerosis, toxic injury by xenobiotics and ischemic-reperfusion damage.

PMID:
1392519
DOI:
10.1016/S0940-2993(11)80202-2
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center