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Acta Radiol. 1992 Sep;33(5):400-4.

Measurements of T1 and T2 over time in formalin-fixed human whole-brain specimens.

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Department of Diagnostic Radiology, Akademiska Sjukhuset, Uppsala University, Sweden.


T1 and T2 were measured in 5 formalin-fixed human whole-brain specimens as a function of time. Gray matter/white matter contrast reversal was observed around the 4th day and was considered to be due to the greater decrease in T1 in gray than in white matter. A possible explanation for this is that the decomposition of the myelin phospholipid structure by formalin somewhat counteracts the general reductive effect of the fixation procedure on relaxation times.

[Indexed for MEDLINE]

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