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Immunol Today. 1992 Jul;13(7):255-8.

Autoimmunity and the ovary.

Author information

1
Dept of Nuclear Medicine, University of Innsbruck, Austria.

Abstract

The ovary was first documented as a target of autoimmunity over three decades ago yet today the aetiology and pathogenesis of autoimmune-mediated premature ovarian failure (POF) are poorly understood. Here, Roy and Helga Moncayo provide a brief overview of human autoimmune-mediated POF and the animal models of POF. They propose a model for the development of the disease, highlighting the role of supraphysiological levels of gonadotropins in inducing selectively antigenic mature ovarian elements.

PMID:
1388652
DOI:
10.1016/0167-5699(92)90006-S
[Indexed for MEDLINE]

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