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Brain Res. 1992 Feb 28;573(2):321-3.

The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.

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Department of Pharmacology, University College London, U.K.


Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5 micrograms) significantly reduces the initial responses of the neurones but not wind up whereas the reverse is true for N-methyl-D-aspartate (NMDA) antagonists. The combination of intrathecal morphine (5 micrograms) and 7-chlorokynurenate (2.5 micrograms), an antagonist at the glycine site of the NMDA receptor, abolishes both the input and wind up of these neurones.

[Indexed for MEDLINE]

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