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Genes Chromosomes Cancer. 1992 Oct;5(3):260-3.

Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp.

Author information

1
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Abstract

Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

PMID:
1384681
DOI:
10.1002/gcc.2870050315
[Indexed for MEDLINE]

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