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Arthritis Rheum. 1992 Oct;35(10):1202-10.

Changes in anti-U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome.

Author information

1
Department of Biochemistry, University of Nijmegen, The Netherlands.

Abstract

OBJECTIVE:

To evaluate correlations between changes in anti-U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years.

METHODS:

Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index.

RESULTS:

All 9 major disease exacerbations were associated with peaks in anti-U1 RNA antibody level.

CONCLUSION:

These results seem to indicate that measuring anti-U1 RNA antibody levels can be useful for monitoring disease activity.

PMID:
1384511
DOI:
10.1002/art.1780351013
[Indexed for MEDLINE]

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