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Mutat Res. 1992 Sep;275(3-6):305-15.

Oxidative and other DNA damages as the basis of aging: a review.

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Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059.


DNA damages occur continuously in cells of living organisms. While most of these damages are repaired, some accumulate. In particular, there is evidence for DNA damage accumulation in non-dividing cells of mammals. These accumulated DNA damages probably interfere with RNA transcription. We consider that the decline in the ability of DNA to serve as a template for gene expression is the primary cause of aging. Oxidative DNA damages are among the best documented and prevalent DNA damages and are likely to be a prominent cause of aging.

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