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Biochemistry. 1992 Sep 15;31(36):8406-14.

Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures.

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  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06511.


A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.

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