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Biochem Biophys Res Commun. 1992 Sep 16;187(2):797-801.

The non specificity of specific nitric oxide synthase inhibitors.

Author information

1
Department of Medicine, VA Medical Center, Minneapolis, MN.

Abstract

L-NAME (Nw-Nitro-L-arginine methylester) and L-NMMA (NG- Monomethyl-L-arginine, monoacetate) are used widely as nitric oxide (NO) synthase inhibitors. Because of their functional groups (alcohols, amines and carboxylates), it appeared that they could interact with iron in a variety of systems. Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine. This suggests that L-NAME and L-NMMA could have effects in iron containing systems found intracellularly apart from their inhibition of (NO) synthesis.

PMID:
1382421
DOI:
10.1016/0006-291x(92)91266-s
[Indexed for MEDLINE]

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