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Biochem Biophys Res Commun. 1992 Sep 16;187(2):1123-7.

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages.

Author information

1
Department of Medicine, Wake Forest University Medical Center Winston-Salem, NC 27157-1042.

Abstract

Prostaglandin H synthase is a key enzyme in the formation of prostaglandins and thromboxane from arachidonic acid. The recent cloning of a second prostaglandin H synthase gene, prostaglandin H synthase-2, which is distinct from the classic prostaglandin H synthase-1 gene, may dramatically alter our concept of how cells regulate prostanoid formation. We have recently shown that the enhanced production of prostanoids by lipopolysaccharide-primed alveolar macrophages involves the induction of a novel prostaglandin H synthase (J. Biol. Chem., (1992), 267, 14547-14550). We report here that the novel PGH synthase induced by lipopolysaccharide in alveolar macrophages is prostaglandin H synthase-2.

PMID:
1382414
DOI:
10.1016/0006-291x(92)91313-f
[Indexed for MEDLINE]

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