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Arthritis Rheum. 1992 Aug;35(8):914-7.

Immunopathology of rheumatoid arthritis. Antikeratin antibodies precede the clinical disease.

Author information

1
Department of Bacteriology and Immunology, University of Helsinki, Finland.

Abstract

OBJECTIVE:

We sought to determine whether circulating antikeratin antibodies (AKA) precede the onset of rheumatoid arthritis (RA).

METHODS:

By matching the registers of 2 previous population studies with the registry of patients receiving antirheumatic drugs several years later, pre-illness serum specimens could be obtained from 39 individuals who subsequently developed RA. AKA were assayed with the standard indirect immunofluorescence technique.

RESULTS:

Ten of 39 serum specimens from individuals who subsequently developed seropositive RA, and 1 of 15 sera from individuals who developed seronegative RA, were positive for IgG-class AKA by immunofluorescence assay. The AKA-positive sera were also positive for rheumatoid factors.

CONCLUSION:

The findings focus attention on the role of pre-illness immunologic events in the pathogenesis of RA.

PMID:
1379430
DOI:
10.1002/art.1780350810
[Indexed for MEDLINE]

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