Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 1992 Jun;15(6):206-11.

How complex is the nicotinic receptor system of insects?

Author information

1
ZMNH, Center for Molecular Neurobiology, University of Hamburg, FRG.

Abstract

In insects, nicotinic acetylcholine receptors (nAChRs) are confined to the nervous system. It is a long-standing open question whether the insect nicotinic cholinergic receptor system is less complex than that of the vertebrate nervous system. Simplicity can be conceived in two ways. (1) Fewer receptor subtypes may exist. (2) Single receptors may have a more primitive (homo-oligomeric) quaternary structure. Recent approaches to the molecular cloning of insect nAChRs may contribute valuable new information to this issue. Thus, the identification of multiple genes encoding proteins similar to vertebrate nAChR subunits implicates a remarkable heterogeneity for these receptors. The discovery of putatively non-ligand-binding subunits hints to the existence of vertebrate-like hetero-oligomeric nAChRs. However, the simultaneous occurrence of homo-oligomeric receptors must still be considered.

PMID:
1378663
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center