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Trends Neurosci. 1992 Jun;15(6):200-1.

An 'anatomical cascade hypothesis' for Alzheimer's disease.

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1
Dept of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.

Abstract

The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated. However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.

PMID:
1378661
[Indexed for MEDLINE]
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