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Biochem Biophys Res Commun. 1992 Jun 30;185(3):1078-82.

Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue.

Author information

1
Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Abstract

When rats were exposed to a cold environment (4 degrees C) for 10 days, tissue glucose utilization was increased in brown adipose tissue (BAT), a tissue specified for non-shivering thermogenesis, but not in skeletal muscle. Cold exposure also caused an increase in the amount of GLUT4, an isoform of glucose transporters expressed in insulin-sensitive tissues, in parallel with an increased cellular level of GLUT4 mRNA. In contrast to BAT, no significant effect of cold exposure was found in skeletal muscle. The results suggest the cold-induced increase in glucose utilization by BAT is attributable, at least in part, to the increased expression of GLUT4.

PMID:
1378263
DOI:
10.1016/0006-291x(92)91736-a
[Indexed for MEDLINE]

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