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Nature. 1992 Jul 9;358(6382):123-8.

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.

Author information

1
Howard Hughes Medical Institute, University of Colorado, Boulder 80309.

Abstract

In catalysis by group I introns, the helix (P1) containing the RNA cleavage site must be positioned next to the guanosine binding site. We have identified a conserved adenine in the catalytic core that contributes to the stability of this arrangement and propose that it accepts a hydrogen bond from a specific 2'-OH in P1. Such base-backbone tertiary interactions may be generally important to the organization of RNA tertiary structure.

PMID:
1377367
DOI:
10.1038/358123a0
[Indexed for MEDLINE]

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