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J Invest Dermatol. 1992 Jul;99(1):114-6.

Expression of transforming growth factor type beta on human epidermal dendritic cells.

Author information

1
Department of Dermatology, Medical School, University of Erlangen-Nuremberg, Federal Republic of Germany.

Abstract

Our study demonstrates that epidermal Langerhans cells (LC) of healthy human skin produce Transforming growth factor-beta (TGF-beta). This multipotent mediator might keep the immunocompetent LC in an "immature" stage, in which they are able to capture and process antigen. Development to potent antigen-presenting cells would become possible after migration from the epidermal network to the draining lymph node to stimulate (auto-)reactive T-cell clones.

PMID:
1376753
DOI:
10.1111/1523-1747.ep12611890
[Indexed for MEDLINE]
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