[Effects of trihexyphenidyl on slow action potentials in guinea pig papillary muscles]

B Jiang; G Q Zhang; J Ke

[Effects of trihexyphenidyl on slow action potentials in guinea pig papillary muscles]

Zhongguo Yao Li Xue Bao. 1992 Mar;13(2):171-3.

[Article in Chinese]

Authors

B Jiang¹, G Q Zhang, J Ke

Affiliation

¹ Department of Pharmacology, He-nan Medical University, Zhengzhou, China.

PMID: 1376014

Abstract

Effects of trihexyphenidyl (THP) were examined on the slow action potentials (SAP) induced by isoproterenol (Iso), histamine (His), Bay k 8644 or tetrodotoxin (TTX), in guinea pig papillary muscles. THP 10, 50, and 100 mumol.L-1 depressed the maximal upstroke velocity (Vmax) and the action potential amplitude (APA) of SAP. These effects were reversed partially by the elevation of the concentration of calcium from 2.0 to 5.6 mmol.L-1. The results suggest that THP can inhibit calcium inflow in myocardium.

MeSH terms

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
Action Potentials / drug effects
Animals
Calcium / pharmacokinetics
Calcium-Transporting ATPases / drug effects
Female
Guinea Pigs
Isoproterenol / pharmacology
Male
Papillary Muscles / physiology*
Tetrodotoxin / pharmacology
Trihexyphenidyl / pharmacology*

Substances

Tetrodotoxin
Trihexyphenidyl
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Calcium-Transporting ATPases
Isoproterenol
Calcium