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Mol Cell Biochem. 1992 Mar 25;110(2):103-11.

Detection of a CpA methylase in an insect system: characterization and substrate specificity.

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1
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore.

Abstract

A cytosine-specific DNA methyltransferase (EC 2.1.1.37) has been purified to near homogeneity from a mealybug (Planococcus lilacinus). The enzyme can methylate cytosine residues in CpG sequences as well as CpA sequences. The apparent molecular weight of the enzyme was estimated as 135,000 daltons by FPLC. The enzyme exhibits a processive mode of action and a salt dependence similar to mammalian methylases. Mealybug methylase exhibits a preference for denatured DNA substrates.

PMID:
1374836
[Indexed for MEDLINE]
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