Format

Send to

Choose Destination
Immunol Today. 1992 Apr;13(4):136-42.

The mechanism of action of cyclosporin A and FK506.

Author information

1
Dept of Chemistry, Harvard University, Cambridge, MA 02138.

Abstract

CsA and FK506 are powerful suppressors of the immune system, most notably of T cells. They act at a point in activation that lies between receptor ligation and the transcription of early genes. Here, Stuart Schreiber and Gerald Crabtree review recent findings that indicate CsA and FK506 operate as prodrugs: they bind endogenous intracellular receptors, the immunophilins, and the resulting complex targets the protein phosphatase, calcineurin, to exert the immunosuppressive effect.

PMID:
1374612
DOI:
10.1016/0167-5699(92)90111-J
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center