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Immunogenetics. 1992;35(6):378-84.

The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1).

Author information

1
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510.

Abstract

We have investigated the role of interferon regulatory factor-1 (IRF-1), an interferon-gamma (IFN-gamma) inducible transcriptional activator, on major histocompatibility complex (MHC) class I gene transcription. IRF-1 alone is sufficient to trans-activate both transfected and endogenous class I genes and the effect of IRF-1 appears to be direct and sequence-specific. These data suggest that IRF-1 is involved in the IFN-gamma mediated induction of MHC class I expression.

PMID:
1374362
DOI:
10.1007/bf00179793
[Indexed for MEDLINE]

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