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Arthritis Rheum. 1992 May;35(5):550-6.

Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.

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1
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874.

Abstract

OBJECTIVE:

To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.

METHODS:

Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection.

RESULTS:

CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.

CONCLUSION:

A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.

PMID:
1374252
[Indexed for MEDLINE]
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