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Mutat Res. 1992 May;267(1):43-54.

Local sequence dependence of rate of base replacement in mammals.

Author information

1
PA Consulting Group, Cambridge Laboratory, Melbourn, Royston, Herts, Great Britain.

Abstract

I have analysed the local sequence context of base replacement changes in 78 processed pseudogenes. Transversions occur more often than transitions in a ratio of 3.37 to 1, and G:C is replaced 1.4 times more frequently than A:T. In addition, the bases to the 5' and 3' of the mutating base also influence the rate at which bases change, purine:pyrimidine and pyrimidine:purine pairs changing 1.2 times as fast as purine:purine and pyrimidine:pyrimidine pairs. I discuss implications of this for the mechanism of DNA polymerization in mammals.

PMID:
1373852
DOI:
10.1016/0027-5107(92)90109-f
[Indexed for MEDLINE]

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