Format

Send to

Choose Destination
See comment in PubMed Commons below
Nihon Hinyokika Gakkai Zasshi. 1992 Mar;83(3):334-7.

[Comparison of selective alpha-1 blockades for alpha-receptors in human hypertrophied prostatic adenomas].

[Article in Japanese]

Author information

1
Department of Urology, Tokyo Medical and Dental University School of Medicine.

Abstract

The adrenergic alpha-1 and -2 adrenoceptors in six human hypertrophied prostatic adenomas were measured in the saturation experiment using 3H-prazosin and 3H-yohimbine. Not only alpha-1 adrenoceptons, but also alpha-2 adrenoceptors were found to exist in large amounts in prostatic adenomas. In the inhibition experiment selective alpha-1 antagonists inhibited the 3H-prozosin or 3H-yohimbine bindings to adenomas. The potency of alpha-1 antagonists in the order prazosin greater than bunazosin greater than alfuzosin greater than urapidil greater than terazosin and that of alpha-2 antagonists is urapidil greater than alfuzosin greater than terazosin greater than bunazosin greater than prazosin. These data suggest that urapidil, alfuzosin and terazosin may affect the human hypertrophied prostatic adenoma like phenoxybenzamine, nonselective alpha-1 antagonist, which was used for benign prostatic hypertrophy.

PMID:
1373456
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
    Loading ...
    Support Center