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Curr Opin Cell Biol. 1992 Feb;4(1):110-6.

Intermediate filament molecular biology.

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Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.


Epidermal keratin intermediate filaments appear to have a structural function. The functions of other intermediate filaments are being elucidated using a combination of molecular genetic methods, including the expression of dominant negative mutant proteins and gene targeting. The differential expression of intermediate filament genes is regulated by both the accessibility of multiple regulatory elements and the activity or level of multiple positive and negative transcription factors.

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