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Acta Endocrinol (Copenh). 1992 Feb;126(2):184-5.

Dramatic response of a metastatic carcinoid tumour to a combination of interferon and octreotide.

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Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.


The combination of alpha-interferon and octreotide has rarely been tested in the treatment of carcinoid syndrome. We describe a patient who was moribund when treated with interferon alone, but enjoyed a dramatic response leading to disappearance of all symptoms, normalization of dU-5-HIAA, and restoration of his normal life-style when octreotide was initiated. Neither interferon nor octreotide could be withdrawn without reappearance of the symptoms, suggesting that the combination of alpha-interferon and octreotide may have synergistic effects in carcinoid syndrome.

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