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Trends Genet. 1992 May;8(5):169-74.

X-chromosome inactivation and cell memory.

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Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.


Mammalian X-chromosome inactivation is an excellent example of the faithful maintenance of a determined chromosomal state. As such, it may provide insight into the mechanisms for cell memory, defined as the faithful maintenance of a determined state in clonally derived progeny cells. We review here the aspects of X-chromosome inactivation that are relevant to cell memory and discuss the various molecular mechanisms that have been proposed to explain its occurrence, with emphasis on DNA methylation and a recently proposed mechanism that depends on the timing of replication.

[Indexed for MEDLINE]

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