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Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Nov-Dec;41(6):1222-30.

[Cholinergic sensitivity as an index of the functional differences in cortical neurons in young and old rabbits].

[Article in Russian]


Acetylcholine-sensitivity of motor cortex neurons was studied in the young and old rabbits. Muscarinic-type excitation in the neurons of old animals was revealed twice less frequently compared to the young ones. The age-related fall in the number of cholinoceptive neurons may be due to general decrease of neuronal activation in the motor cortex during aging. Changes in functional properties of motor cortex neurons with age may have a result that firing rate of movement related neurons becomes insufficient for the effective control of motor function.

[Indexed for MEDLINE]

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