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Trends Biotechnol. 1991 Dec;9(12):415-21.

Poliovirus antigen chimeras.

Author information

1
Department of Microbiology, University of Reading, Whiteknights, UK.

Abstract

Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of hybrid viruses (chimeras) possessing novel antigenicity. The potential applications of these 'epitope-presentation systems' include their use as immunogens, as antigens for serodiagnosis, and as vaccines.

PMID:
1369352
DOI:
10.1016/0167-7799(91)90142-5
[Indexed for MEDLINE]

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